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Lutetium (177 Lu) chloride is a radioactive compound used for the radiolabeling of pharmaceutical molecules, aimed either as an anti-cancer therapy or for scintigraphy (medical imaging). [ 5 ] [ 6 ] It is an isotopomer of lutetium(III) chloride containing the radioisotope 177 Lu , which beta decays with a half-life of 6.64 days.
Forty radioisotopes have been characterized, with the most stable, besides 176 Lu, being 174 Lu with a half-life of 3.31 years, and 173 Lu with a half-life of 1.37 years. All of the remaining radioactive isotopes have half-lives that are less than 9 days, and the majority of these have half-lives that are less than half an hour.
Lutetium (177 Lu) oxodotreotide or 177 Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors. [5] It is a radiolabeled somatostatin analog. [3] [6] [7]
Lutetium is a chemical element; it has symbol Lu and atomic number 71. It is a silvery white metal , which resists corrosion in dry air, but not in moist air. Lutetium is the last element in the lanthanide series, and it is traditionally counted among the rare earth elements ; it can also be classified as the first element of the 6th-period ...
Lutetium (177 Lu) vipivotide tetraxetan, sold under the brand name Pluvicto, is a radiopharmaceutical medication used for the treatment of prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC). [5] [6] Lutetium (177 Lu) vipivotide tetraxetan is a targeted radioligand therapy. [6] [8]
For example, the bremsstrahlung emission from 90 Y and gamma emissions from 177 Lu can be detected by a gamma camera. In other cases, imaging can be performed by labelling a suitable radionuclide to the same peptide as used for therapy. [ 22 ]
Lutetium(III) chloride or lutetium trichloride is the chemical compound composed of lutetium and chlorine with the formula LuCl 3.It forms hygroscopic white monoclinic crystals [3] and also a hygroscopic hexahydrate LuCl 3 ·6H 2 O. [6] Anhydrous lutetium(III) chloride has the YCl 3 (AlCl 3) layer structure with octahedral lutetium ions.
The area of the blue region converges to Euler's constant. Euler's constant (sometimes called the Euler–Mascheroni constant) is a mathematical constant, usually denoted by the lowercase Greek letter gamma (γ), defined as the limiting difference between the harmonic series and the natural logarithm, denoted here by log: