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Argatroban is used as an anticoagulant in individuals with thrombosis and heparin-induced thrombocytopenia. Often these individuals require long-term anticoagulation. If warfarin is chosen as the long-term anticoagulant, this poses particular challenges due to the falsely elevated prothrombin time and INR caused by argatroban.
Argatroban has been approved in the USA since 2000 for the treatment of thrombosis in patients with HIT and 2002 for anticoagulation in patients with a history of HIT or are at risk of HIT undergoing percutaneous coronary interventions (PCI). [10] [19] It was first introduced in Japan in 1990 for treatment of peripheral vascular disorders. [19]
Blood thinners, Pain medication [1] Thrombophlebitis is a phlebitis ( inflammation of a vein ) related to a thrombus (blood clot). [ 2 ] When it occurs repeatedly in different locations, it is known as thrombophlebitis migrans ( migratory thrombophlebitis ).
Arthritis is more common in people assigned female at birth. However, some types ( specifically gout) are more common in individuals assigned male at birth. Family history.
According to a systematic review, people with HIT treated with lepirudin showed a relative risk reduction of clinical outcome (death, amputation, etc.) to be 0.52 and 0.42 when compared to patient controls. In addition, people treated with argatroban for HIT showed a relative risk reduction of the above clinical outcomes to be 0.20 and 0.18. [13]
Discontinuation of heparin is critical in a case of heparin-induced thrombocytopenia (HIT). Beyond that, however, clinicians generally treat to avoid thrombosis. [32] Treatment may include a direct thrombin inhibitor, such as lepirudin or argatroban. Other "blood thinners" sometimes used in this setting include bivalirudin and fondaparinux.
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It is believed that the most common origin site of thrombus is from a deep vein thrombosis (DVT), however, in most patients with suspected paradoxical embolism no evidence of a DVT is found. [8] Symptoms of a DVT will include unilateral leg swelling and pain, warmth, and redness of the affected area. [ 9 ]
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