Search results
Results from the WOW.Com Content Network
The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
Locomotor activity is a measure of animal behavior which is employed in scientific research. [1] [2]Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. [3]
The neurotransmitter dopamine is a key candidate for explanation of reinforcing actions drugs. [6] [7] It's unclear to which extent NET is involved in the reinforcing actions of cocaine (an SNDRI). [8] Animal studies show evidence that inhibiting the SERT might reduce cocaine intake. [9]
Cocaine is a non-selective, competitive inhibitor of monoamine transporters, sharing a similar mechanism with that of methylphenidate. Cocaine interacts with DAT, SERT, and NET, although the behavioral and reinforcing effects of cocaine depend on its inhibition of DAT and the increase in extracellular dopamine. [1]
JHW-007 is a cocaine analogue and a high affinity atypical dopamine reuptake inhibitor that is being researched for the treatment of cocaine addiction.JHW-007 has been found to blunt the psychostimulant effects of cocaine and reduce self-administration in rodents. [1]
This suggests a positive neuromodulatory action of CART on the effects of psychostimulants in rats. [18] CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene is associated with alcoholism. [19] By inhibiting the rewarding effects of cocaine, CART has a potential use in treating cocaine ...
Cocaine addiction results from complex molecular changes in the brain following multiple exposures to cocaine. [16] Dynorphins have been shown to be an important part of this process. Although a single exposure to cocaine does not affect brain dynorphin levels, repeated exposures to the drug increases dynorphin concentrations in the striatum ...
The potential for cocaine addiction is thought to be a result of its effects on dopamine transporters in the CNS, while it has been suggested that the life-threatening cardiovascular effects of cocaine may involve the inhibition of NETs at sympathetic and CNS autonomic synapses. [28]