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The first-ever affinity table, which was based on displacement reactions, was published in 1718 by the French chemist Étienne François Geoffroy. Geoffroy's name is best known in connection with these tables of "affinities" ( tables des rapports ), which were first presented to the French Academy of Sciences in 1718 and 1720.
Avidity (functional affinity) is the accumulated strength of multiple affinities. [2] For example, IgM is said to have low affinity but high avidity because it has 10 weak binding sites for antigen as opposed to the 2 stronger binding sites of IgG, IgE and IgD with higher single binding affinities. [citation needed]
The surface-area-to-volume ratio has physical dimension inverse length (L −1) and is therefore expressed in units of inverse metre (m −1) or its prefixed unit multiples and submultiples. As an example, a cube with sides of length 1 cm will have a surface area of 6 cm 2 and a volume of 1 cm 3. The surface to volume ratio for this cube is thus
Weak affinity chromatography [29] (WAC) is an affinity chromatography technique for affinity screening in drug development. [30] [31] WAC is an affinity-based liquid chromatographic technique that separates chemical compounds based on their different weak affinities to an immobilized target. The higher affinity a compound has towards the target ...
A V D greater than the total volume of body water (approximately 42 liters in humans [5]) is possible, and would indicate that the drug is highly distributed into tissue. In other words, the volume of distribution is smaller in the drug staying in the plasma than that of a drug that is widely distributed in tissues. [6]
Mendeleev organized the elements based on atomic weight, leaving empty spaces where he believed undiscovered elements would take their places. [3] Mendeleev's discovery of this trend allowed him to predict the existence and properties of three unknown elements, which were later discovered by other chemists and named gallium , scandium , and ...
The affinity laws are useful as they allow the prediction of the head discharge characteristic of a pump or fan from a known characteristic measured at a different speed or impeller diameter. The only requirement is that the two pumps or fans are dynamically similar, that is, the ratios of the fluid forced are the same.
Complementary antonyms are word pairs whose meanings are opposite but whose meanings do not lie on a continuous spectrum (push, pull). Relational antonyms are word pairs where opposite makes sense only in the context of the relationship between the two meanings (teacher, pupil). These more restricted meanings may not apply in all scholarly ...