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Ramelteon is excreted 84% in urine and 4% in feces. [3] Less than 0.1% of drug is excreted as unchanged ramelteon. [3] Elimination of ramelteon is essentially complete by 96 hours following a single dose. [3] The elimination half-life of ramelteon is 1 to 2.6 hours while the half-life of M-II, the major active metabolite of ramelteon, is 2 to 5 ...
Here are links to possibly useful sources of information about Ramelteon. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
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Tasimelteon, sold under the brand name Hetlioz, is a medication approved by the U.S. Food and Drug Administration (FDA) [3] in January 2014, for the treatment of non-24-hour sleep–wake disorder (also called non-24, N24 and N24HSWD). [4]
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