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[128] [17] The increase in the fraction of estradiol bound to SHBG results in a significant decrease in the percentage of free or unbound and hence bioactive estradiol. [ 1 ] [ 17 ] As a result, the bioavailability and potency of oral estradiol may be diminished relative to parenteral estradiol routes by some amount.
HIV is now known to spread between CD4 + T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms. [95] In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter. [ 95 ]
Some presidential primary elections were severely disrupted by COVID-19-related issues, including long lines at polling places, greatly increased requests for absentee ballots, and technology issues. [108] Due to a shortage of election workers able or willing to work during the pandemic, the number of polling places was often greatly reduced.
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