Search results
Results from the WOW.Com Content Network
IKK is composed of a heterodimer of the catalytic IKKα and IKKβ subunits and a "master" regulatory protein termed NEMO (NF-κB essential modulator) or IKKγ. When activated by signals, usually coming from the outside of the cell, the IκB kinase phosphorylates two serine residues located in an IκB regulatory domain.
The regulatory IKK-γ subunit, or NEMO, is composed of two coiled coil domains, a leucine zipper dimerization domain, and a zinc finger-binding domain. [6] Specifically, the NH2-terminus of NEMO binds to the NBD sequences on IKK-α and IKK-β, leaving the rest of NEMO accessible for interacting with regulatory proteins. [7]
IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB.
The NBD peptide was designed by identifying the amino acid binding sequence on IKK-α and IKK-β to which NEMO binds. [12] A small region on the carboxyl terminus of IKK-α (L738-L743) and IKK-β (L737-L742) is essential for a stable interaction with NEMO and for the assembly of the active IKK complex. Henceforth this region is called the NEMO ...
IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus. [ 9 ] Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and ...
TBK1 is a non-canonical IKK kinase that phosphorylates the nuclear factor kB (NFkB). It shares sequence homology with canonical IKK. [5]The N-terminus of the protein contains the kinase domain (region 9-309) and the ubiquitin-like domain (region 310-385).
18035 Ensembl ENSG00000100906 ENSMUSG00000021025 UniProt P25963 Q9Z1E3 RefSeq (mRNA) NM_020529 NM_010907 RefSeq (protein) NP_065390 NP_035037 Location (UCSC) Chr 14: 35.4 – 35.4 Mb Chr 12: 55.54 – 55.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IκBα (n uclear f actor of k appa light polypeptide gene enhancer in B -cells i nhibitor a lpha; NFKBIA) is one member of a family ...
NEMO is the modulator protein in the IKK inhibitor complex that, when activated, phosphorylates the inhibitor of the NF-κB transcription factors allowing for the translocation of transcription factors into the nucleus. The link between IKBKG mutations and NEMO deficiency was identified in 1999.