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In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: . ATP + IκB protein ADP + IκB phosphoprotein. Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.
12675 Ensembl ENSG00000213341 ENSMUSG00000025199 UniProt O15111 Q60680 RefSeq (mRNA) NM_001278 NM_001320928 NM_001162410 NM_007700 RefSeq (protein) NP_001269 NP_001307857 n/a Location (UCSC) Chr 10: 100.19 – 100.23 Mb Chr 19: 44.06 – 44.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or ...
18035 Ensembl ENSG00000100906 ENSMUSG00000021025 UniProt P25963 Q9Z1E3 RefSeq (mRNA) NM_020529 NM_010907 RefSeq (protein) NP_065390 NP_035037 Location (UCSC) Chr 14: 35.4 – 35.4 Mb Chr 12: 55.54 – 55.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IκBα (n uclear f actor of k appa light polypeptide gene enhancer in B -cells i nhibitor a lpha; NFKBIA) is one member of a family ...
7099 21898 Ensembl ENSG00000136869 ENSMUSG00000039005 UniProt O00206 Q9QUK6 RefSeq (mRNA) NM_138557 NM_003266 NM_138554 NM_138556 NM_021297 RefSeq (protein) NP_003257 NP_612564 NP_612567 NP_067272 Location (UCSC) Chr 9: 117.7 – 117.72 Mb Chr 4: 66.75 – 66.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Toll-like receptor 4 (TLR4), also designated as CD284 (cluster of ...
16150 Ensembl ENSG00000104365 ENSMUSG00000031537 UniProt O14920 O88351 RefSeq (mRNA) NM_001190720 NM_001190721 NM_001190722 NM_001242778 NM_001556 NM_001159774 NM_010546 RefSeq (protein) NP_001177649 NP_001229707 NP_001547 NP_001153246 NP_034676 Location (UCSC) Chr 8: 42.27 – 42.33 Mb Chr 8: 23.15 – 23.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IKK-β also known as ...
Mechanism of NF-κB action.The classic "canonical" NF-κB complex is a heterodimer of p50 and RelA, [1] as shown. NF-κB waits for activation in the cytosol, complexed with the inhibitory protein IκBα.
Mutations in the IKBKG gene results in incontinentia pigmenti, [7] hypohidrotic ectodermal dysplasia, [8] and several other types of immunodeficiencies.. Incontinentia Pigmenti (IP) is an X-linked dominant disease caused by a mutation in the IKBKG gene.
IKBKAP (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein) is a human gene encoding the IKAP protein, which is ubiquitously expressed at varying levels in all tissue types, including brain cells. [1]