Search results
Results from the WOW.Com Content Network
18035 Ensembl ENSG00000100906 ENSMUSG00000021025 UniProt P25963 Q9Z1E3 RefSeq (mRNA) NM_020529 NM_010907 RefSeq (protein) NP_065390 NP_035037 Location (UCSC) Chr 14: 35.4 – 35.4 Mb Chr 12: 55.54 – 55.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IκBα (n uclear f actor of k appa light polypeptide gene enhancer in B -cells i nhibitor a lpha; NFKBIA) is one member of a family ...
Following IKK-mediated phosphorylation of IκBα and the subsequent decrease in IκB abundance, the activated IKK kinase subunits undergo extensive carboxy-terminal autophosphorylation, reaching a low activity state that is further susceptible to complete inactivation by phosphatases once upstream inflammatory signaling diminishes.
The newly synthesized IκBα then re-inhibits NF-κB and, thus, forms an auto feedback loop, which results in oscillating levels of NF-κB activity. [40] In addition, several viruses, including the AIDS virus HIV, have binding sites for NF-κB that controls the expression of viral genes, which in turn contribute to viral replication or viral ...
16150 Ensembl ENSG00000104365 ENSMUSG00000031537 UniProt O14920 O88351 RefSeq (mRNA) NM_001190720 NM_001190721 NM_001190722 NM_001242778 NM_001556 NM_001159774 NM_010546 RefSeq (protein) NP_001177649 NP_001229707 NP_001547 NP_001153246 NP_034676 Location (UCSC) Chr 8: 42.27 – 42.33 Mb Chr 8: 23.15 – 23.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IKK-β also known as ...
RELA nuclear localization signal used to be sequestered by IκBα is now exposed, and rapid translocation of the NF-κB occurs. In parallel, there is a non-classical NF-κB activation pathway involving the proteolytic cleavage of p100 into p52 instead of p50. This process does not require RELA, hence will not be discussed in detail here. [10]
Binding of IKK-γ to IKK-α and IKK-β subunits activates the IKK complex leading to phosphorylation of IκB kinase, IκBα, and release of NF-κB dimers p105 and RELA to translocate to the nucleus and activate transcription of NF-κB responsive genes. In the presence of the NBD peptide, the IKK complex remains inactive and IκBα sequesters NF ...
In contrast, ubiquitin-independent degrons are not necessary for the polyubiquitination of their protein. For example, the degron on IκBα, a protein involved in the regulation of the immune system, was not shown to be involved in ubiquitination since its addition to green fluorescent protein did not increase ubiquitination. [1]
The NLS is an additional characteristic structural element of only atypical IκB proteins, which is responsible for the localization of the protein into the nucleus. In contrast, classical inhibitors, e.g. IκBα and IκBβ, are located in the cytoplasm. A high resolution structure of NFKBID is not available yet. Scheme of NFKBID.