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  2. Sodium channel - Wikipedia

    en.wikipedia.org/wiki/Sodium_channel

    The family of sodium channels has 9 known members, with amino acid identity >50% in the trans-membrane segments and extracellular loop regions. A standardized nomenclature for sodium channels is currently used and is maintained by the IUPHAR. [11] The proteins of these channels are named Na v 1.1 through Na v 1.9.

  3. Persistent sodium current - Wikipedia

    en.wikipedia.org/wiki/Persistent_Sodium_Current

    Persistent sodium current generation is hypothesized to occur by the incomplete inactivation of the voltage-gated sodium channel current (INa), where the channel becomes constitutively active and conducts sodium, creating a "persistently active" inward sodium current. Upon depolarization, the four identical motifs of the sodium channel (which ...

  4. Epithelial sodium channel - Wikipedia

    en.wikipedia.org/wiki/Epithelial_sodium_channel

    The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.

  5. Hyponatremia - Wikipedia

    en.wikipedia.org/wiki/Hyponatremia

    A blood test demonstrating a serum sodium less than 135 mmol/L is diagnostic for hyponatremia. [34] The history and physical exam are necessary to help determine if the person is hypovolemic, euvolemic, or hypervolemic, which has important implications in determining the underlying cause.

  6. SCNN1D - Wikipedia

    en.wikipedia.org/wiki/SCNN1D

    n/a Ensembl ENSG00000162572 n/a UniProt P51172 n/a RefSeq (mRNA) NM_001130413 NM_002978 n/a RefSeq (protein) NP_001123885 n/a Location (UCSC) Chr 1: 1.28 – 1.29 Mb n/a PubMed search n/a Wikidata View/Edit Human The SCNN1D gene encodes for the δ (delta) subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α ...

  7. SCNN1B - Wikipedia

    en.wikipedia.org/wiki/SCNN1B

    The flow of sodium ions across epithelia affects osmolarity of the extracellular fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure. [7] As ENaC is strongly inhibited by amiloride, it is also referred to as an "amiloride-sensitive sodium channel".

  8. Sodium voltage-gated channel alpha subunit 9 - Wikipedia

    en.wikipedia.org/wiki/Sodium_voltage-gated...

    Sodium voltage-gated channel alpha subunit 9 (also Na v 1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene. [5] [6] [7] It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal root ganglion (DRG) and trigeminal ganglion; and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.

  9. Voltage-gated sodium channel - Wikipedia

    en.wikipedia.org/wiki/Voltage-gated_sodium_channel

    Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na +. They are the main channels involved in action potential of excitable cells.

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