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The name isotretinoin is the same root tretinoin plus the prefix iso-. Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin. Given that retinoic is pronounced / ˌ r ɛ t ɪ ˈ n oʊ ɪ k /, [43] [44] [42] [45] it is natural that / ˌ t r ɛ t ɪ ˈ n oʊ ɪ n / is a commonly heard pronunciation.
Retinoic acid administered as a drug (see tretinoin and alitretinoin) causes significant toxicity that is distinct from normal retinoid biology. [6] All-trans-retinoic acid is the major occurring retinoic acid, while isomers like 13-cis- and 9-cis-retinoic acid are also present in much lower levels. [7]
Retinol, also called vitamin A1, is a fat-soluble vitamin in the vitamin A family that is found in food and used as a dietary supplement. [ 3 ] Retinol or other forms of vitamin A are needed for vision, cellular development, maintenance of skin and mucous membranes, immune function and reproductive development. [ 3 ]
Vitamin A is a fat-soluble vitamin, a category that also includes vitamins D, E and K. The vitamin encompasses several chemically related naturally occurring compounds or metabolites, i.e., vitamers, that all contain a β- ionone ring. [ 4 ]
Isotretinoin, also known as 13-cis-retinoic acidand sold under the brand name Accutaneamong others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acneor moderate acne that is unresponsive to antibiotics.[6] Isotretinoin is used off-label to treat basal cell carcinomaand ...
Contents. Retinoid. 1st, 2nd, 3rd-generation retinoid compounds. The retinoids are a class of chemical compounds that are natural derivatives of vitamin A or are chemically related to it. Synthetic retinoids are used in medicine where they regulate skin health, immunity and bone disorders.
Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. [2][3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids.
Albert Kligman. Albert Montgomery Kligman (March 17, 1916 – February 9, 2010) [1] was an American dermatologist who co-invented Retin-A, the acne medication, with James Fulton in 1969. [2] Kligman performed human experiments on inmates at Holmesburg Prison in Philadelphia, which led to a well-documented scandal years later.