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Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells. Haematopoiesis (/ h ɪ ˌ m æ t ə p ɔɪ ˈ iː s ɪ s, ˌ h iː m ə t oʊ-, ˌ h ɛ m ə-/; [1] [2] from Ancient Greek αἷμα (haîma) 'blood' and ποιεῖν (poieîn) 'to make'; also hematopoiesis in American English, sometimes h(a)emopoiesis) is the formation of blood cellular ...
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. [ 2 ] In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). [ 3 ] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells.
Normally, bone continuously breaks down and rebuilds—old bone is resorbed and replaced with new bone. The process keeps the skeleton strong and helps it to maintain a balance of minerals. [23] In the course of avascular necrosis, however, the healing process is usually ineffective and the bone tissues break down faster than the body can ...
Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to all of the different mature blood cell types and tissues. [ 2 ][ 3 ] HSCs are self-renewing cells: when they differentiate, at least some of their daughter cells remain as HSCs, so the pool of stem cells is not depleted.
Hematopoietic stem cells (HSCs) are the stem cells [ 1 ] that give rise to other blood cells. This process is called haematopoiesis. [ 2 ] In vertebrates, the first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to ...
This is broadly termed hematopoiesis. [ 2 ] This event requires a special environment, termed the hematopoietic stem cell niche, which provides the protection and signals necessary to carry out the differentiation of cells from HSC progenitors. [ 2 ] This stem-cell niche relocates from the yolk sac to eventually rest in the bone marrow of mammals.
Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary. They are cells that support the function of the parenchymal cells of that organ. The most common stromal cells include fibroblasts and pericytes.
A granulocyte, also referred to as a polymorphonuclear leukocyte (PMN), is a type of white blood cell that has multi lobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell. [ 1 ] Granulopoiesis takes place in the bone marrow. [ 2 ] It leads to the production of three types of mature ...