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Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve ...
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
A disposable nitrile rubber glove. The uses of nitrile rubber include disposable non-latex gloves, automotive transmission belts, hoses, O-rings, gaskets, oil seals, V belts, synthetic leather, printer's form rollers, and as cable jacketing; NBR latex can also be used in the preparation of adhesives and as a pigment binder. [citation needed]
Radin, for her part, has narrowed her scar-minimizing routine to a mix of products—she’s still experimenting with application order—including Hero Rescue Balm, Mederma Scar Gel, Bio-Oil ...
Gritstone bio started also started a phase 1 trial of an saRNA COVID-19 vaccine in 2021, used as a booster vaccine, with interim results published in 2023. [105] The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection ...
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Oil pulling. Oil pulling, the practice of swishing oil around in your mouth for potential oral health benefits, has existed for thousands of years and predates tooth brushing.
Whale oil is oil obtained from the blubber of whales. [1] Oil from the bowhead whale was sometimes known as train-oil , which comes from the Dutch word traan ("tear drop"). Sperm oil , a special kind of oil used in the cavities of sperm whales , differs chemically from ordinary whale oil: it is composed mostly of liquid wax .