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Speedball, powerball, or over and under [1] is the polydrug mixture of a stimulant with a depressant, usually an opioid.The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl.
Depressants are psychoactive drugs that temporarily diminish the function or activity of a specific part of the body or mind. [92] Colloquially, depressants are known as "downers", and users generally take them to feel more relaxed and less tense. Examples of these kinds of effects may include anxiolysis, sedation, and hypotension.
Additionally, stimulants like cocaine, methamphetamine, and even caffeine cause dehydration and dry mouth. Since saliva is an important mechanism in maintaining one's oral pH level, people who use cocaine over a long period of time who do not hydrate sufficiently may experience demineralization of their teeth due to the pH of the tooth surface ...
The hope is that it will trigger a rush of clinical trial testing for drug treatments for stimulant use disorder, aiming to fill a major gap in the response to the overdose crisis in the U.S ...
Cocaine is a stimulant but is not normally prescribed therapeutically for its stimulant properties, although it sees clinical use as a local anesthetic, in particular in ophthalmology. [152] Most cocaine use is recreational and its abuse potential is high (higher than amphetamine), and so its sale and possession are strictly controlled in most ...
A drug combination chart designed for harm reduction by TripSit [1]. Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances.
Cocaine has a similar potential to induce temporary psychosis [22] with more than half of cocaine abusers reporting at least some psychotic symptoms at some point. [23] Typical symptoms include paranoid delusions that they are being followed and that their drug use is being watched, accompanied by hallucinations that support the delusional ...
In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency units in the USA every year because of this; thus, development of safer substitute medications for cocaine abuse could potentially have significant benefits for public ...