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Immunohistochemical markers that have been suggested to be useful in making an accurate diagnosis of Bas-SqCC include positivity for p63 and high molecular weight keratin (i.e. 34betaE12), and lack of expression of thyroid transcription factor-1 (TTF-1). [8] [9] [10]
21869 Ensembl ENSG00000136352 ENSMUSG00000001496 UniProt P43699 P50220 RefSeq (mRNA) NM_001079668 NM_003317 NM_001146198 NM_009385 RefSeq (protein) NP_001073136 NP_003308 NP_033411 NP_001390509 Location (UCSC) Chr 14: 36.52 – 36.52 Mb Chr 12: 56.58 – 56.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1 ...
22130 Ensembl ENSG00000125482 ENSMUSG00000026803 UniProt Q15361 Q62187 RefSeq (mRNA) NM_001205296 NM_007344 NM_009442 RefSeq (protein) NP_001192225 NP_031370 NP_033468 Location (UCSC) Chr 9: 132.38 – 132.41 Mb Chr 2: 28.95 – 28.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene. References ...
Markers can help with assessing prognosis, surveilling patients after surgical removal of tumors, and even predicting drug-response and monitor therapy. [1] Tumor markers can be molecules that are produced in higher amounts by cancer cells than normal cells, but can also be produced by other cells from a reaction with the cancer. [2]
If cancer has spread beyond that, it is said to be ES. Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for the highest mortality rates among both men and women. When associated with the lung, SCLC is sometimes called "oat cell carcinoma" due to the flat cell shape and scanty cytoplasm. Small cell mesothelioma ...
The prognosis of patients with non-small-cell lung cancer improved significantly with the introduction of immunotherapy. [59] People with tumor PDL-1 expressed over half or more of the tumor cells achieved a median overall survival of 30 months with pembrolizumab. [63] [64]
Many small series have suggested that the prognosis of lung tumors with giant cells is worse than that of most other forms of non-small-cell lung cancer (NSCLC), [11] including squamous cell carcinoma, [42] and spindle cell carcinoma. [42] The overall five-year survival rate in GCCL varies between studies but is generally considered to be very low.
Morphological differential diagnosis. Multifocal micronodular pneumocyte hyperplasia (MMPH) [1] in situ pulmonary adenocarcinoma (bronchioloalveolar carcinoma – BAC)