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[19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...
Blood pressure drugs aren't the only commonly prescribed medications that grapefruit juice can mess with — they also include anticoagulants that help prevent blood clots, organ-transplant ...
Drugs approved after June 24, 1938, but before 1962 had a limited time to be reviewed for efficacy to remain on the market. This was known as the Drug Efficacy Study Implementation (DESI). As of today there are only a handful of drugs still on the DESI list [ 61 ] and in 2006, the FDA stated it was not aware of any grandfathered drugs.
Furanocoumarins in grapefruit juice (i.e. bergamottin and dihydroxybergamottin) inhibit the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of most statins (however, it is a major inhibitor of only lovastatin, simvastatin, and to a lesser degree, atorvastatin) and some other medications [130] (flavonoids (i.e. naringin) were ...
Several medications such as statins and calcium-channel blockers shouldn’t be taken with grapefruit or its juice because of its enzyme-binding ability, which means the medications may pass from ...
Lovastatin was patented in 1979 and approved for medical use in 1987. [4] It is on the World Health Organization's List of Essential Medicines. [5] It is available as a generic medication. [2] In 2022, it was the 111th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]
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