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It is likely that such effects have an effect on the blood supply to the brain. That such an effect might well lead to damage to the brain seems likely. Therefore it is regarded that the association between exposure to air pollutants and effects on cognitive decline and dementia as likely to be causal with respect to this mechanism. [65]
For one gas molecule to be categorized as a gasotransmitter, all of the following criteria should be met. [4] [3] It is a small molecule of gas; It is freely permeable to membranes. As such, its effects do not rely on the cognate membrane receptors. It can have endocrine, paracrine, and autocrine effects.
For example, phosgene was initially blamed for the Bhopal disaster, but investigations proved methyl isocyanate to be responsible for the numerous poisonings and fatalities. Recent major incidents happened in January 2010 and May 2016. An accidental release of phosgene gas at a DuPont facility in West Virginia killed one employee in 2010. [41]
In low concentrations, phosgene’s odor resembles freshly cut hay or grass. Because of this, the gas may not be noticed and symptoms may appear slowly. Phosgene directly reacts with amine, sulfhydryl, and alcohol groups, adversely affecting cell macromolecules and metabolism. The direct toxicity to the cells leads to an increase in capillary ...
Traces of a toxic, colorless gas were found at the headquarters of Sweden’s security agency where a suspected gas leak last week forced authorities to evacuate some 500 people from the facility ...
Gaseous signaling molecules are gaseous molecules that are either synthesized internally (endogenously) in the organism, tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the case of oxygen) and that are used to transmit chemical signals which induce certain physiological or biochemical changes in the organism, tissue or ...
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. [1]Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios.
The potentially fatal dose is only slightly higher than the dose having any effect at all, and the effects of a fatal dose are so rapid that there is little time for treatment. [5] The median lethal dose (LD 50 ), the exposure required to kill half of a tested population, as estimated for 70 kg human males via exposure to the skin is reported ...