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Extra-wide double-fold bias tape being sewn as a binding on a decorative quilt An example of single-fold bias tape An example of double-fold bias tape Commercial bias binding foot fed with bias binding, producing bias binding tape. Bias tape or bias binding is a narrow strip of fabric, typically plain weave, cut on the bias.
Derivatization-free approaches aim to infer drug-target interactions by observing changes in protein stability or drug chromatography upon binding. Computational techniques complement the chemoproteomic toolkit as parallel lines of evidence supporting potential drug-target pairs, and are used to generate structural models that inform lead ...
In immunology, epitope mapping is the process of experimentally identifying the binding site, or epitope, of an antibody on its target antigen (usually, on a protein). [ 1 ] [ 2 ] [ 3 ] Identification and characterization of antibody binding sites aid in the discovery and development of new therapeutics , vaccines , and diagnostics .
Cross-linking and immunoprecipitation (CLIP, or CLIP-seq) is a method used in molecular biology that combines UV crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding of post-transcriptional regulatory networks.
Within chemistry, a Job plot, otherwise known as the method of continuous variation or Job's method, is a method used in analytical chemistry to determine the stoichiometry of a binding event. The method is named after Paul Job and is also used in instrumental analysis and advanced chemical equilibrium texts and research articles.
Combining with other new techniques, this method can be used to screen protein–protein interactions and their modulators, [3] DERB. [4] Affinity electrophoresis as used for estimation of binding constants, as for instance in lectin affinity electrophoresis or characterization of molecules with specific features like glycan content or ligand ...
Tandem affinity purification (TAP) is an immunoprecipitation-based purification technique for studying protein–protein interactions.The goal is to extract from a cell only the protein of interest, in complex with any other proteins it interacted with.
Bio-layer interferometry platforms achieve high throughput by utilizing a "Dip and Read" format. [1] The biosensor tips themselves are transported directly to the desired sample and "dipped" into their respective compartment, eliminating the needs for micro-fluidics and the complications (clogging, purification) that come with it.