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Metaphase (from Ancient Greek μετα- beyond, above, transcending and from Ancient Greek φάσις (phásis) 'appearance') is a stage of mitosis in the eukaryotic cell cycle in which chromosomes are at their second-most condensed and coiled stage (they are at their most condensed in anaphase). [1]
Steps of the cell cycle. The G 2-M checkpoint occurs between the G 2 and M phases. G2-M arrest. The G 2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired.
Biochemically, the end of G 2 phase occurs when a threshold level of active cyclin B1/CDK1 complex, also known as Maturation promoting factor (MPF) has been reached. [4] The activity of this complex is tightly regulated during G 2. In particular, the G 2 checkpoint arrests cells in G 2 in response to DNA damage through inhibitory regulation of ...
Biological illustration is the use of technical illustration to visually communicate the structure and specific details of biological subjects of study. This can be used to demonstrate anatomy , explain biological functions or interactions, direct surgical procedures, distinguish species, and other applications.
Four phases of mitosis: prophase, metaphase, anaphase, and telophase: Prophase: Chromatin into chromosomes, the nuclear envelope breaks down, chromosomes attach to spindle fibers by their centromeres. Metaphase: Chromosomes line up along the metaphase plate (center of the cell). Anaphase: Sister chromatids are pulled to opposite poles of the cell.
The oncologist, per the Stanford Medicine blog Scope, was diagnosed with non-small cell cancer — also known as never-smoker lung cancer — in early May, around a month before his 50th birthday.
The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...
The presence of multipolar spindles in cancer cells is one of many differences from normal cells which can be seen under a microscope.Cancer is defined by uncontrolled cell growth and malignant cells can undergo cell division with multipolar spindles because they can group multiple centrosomes into two spindles.