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Unlike other crosslinking agents, aldehyde-induced crosslinking is an intrinsically reversible process. NMR structure of these types of agents as interstrand crosslinks show that a 5'-GC adduct results in minor distortion to DNA, however a 5'-CG adduct destabilizes the helix and induces a bend and twist in the DNA.
IUPAC definition for a crosslink in polymer chemistry In chemistry and biology , a cross-link is a bond or a short sequence of bonds that links one polymer chain to another. These links may take the form of covalent bonds or ionic bonds and the polymers can be either synthetic polymers or natural polymers (such as proteins ).
Curing is a chemical process employed in polymer chemistry and process engineering that produces the toughening or hardening of a polymer material by cross-linking of polymer chains. [1] Even if it is strongly associated with the production of thermosetting polymers , the term "curing" can be used for all the processes where a solid product is ...
In 1984 John T. Lis and David Gilmour, at the time a graduate student in the Lis lab, used UV irradiation, a zero-length protein-nucleic acid crosslinking agent, to covalently cross-link proteins bound to DNA in living bacterial cells. Following lysis of cross-linked cells and immunoprecipitation of bacterial RNA polymerase, DNA associated with ...
Cross-linking and immunoprecipitation (CLIP, or CLIP-seq) is a method used in molecular biology that combines UV crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding of post-transcriptional regulatory networks.
Intercalation induces structural distortions. Left: unchanged DNA strand. Right: DNA strand intercalated at three locations (black areas). In biochemistry, intercalation is the insertion of molecules between the planar bases of deoxyribonucleic acid (DNA).
These abnormalities correlated well with decreased cross-linking of collagen and elastin. [ 19 ] Developmentally, reduced lysyl oxidase activity have been implicated in Menkes disease and occipital horn syndrome , two X-linked recessive disorders characterized by a mutation in a gene coding for a protein involved in copper transport.
Cross-linking may refer to Cross-link, a chemical bond of one polymer chain to another; Corneal collagen cross-linking, a parasurgical treatment for corneal ectasia ...