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  2. Mechanism of action - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action

    Common examples of drugs that work in this way are antacids and laxatives. [2] In contrast, a mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance.

  3. Mode of action - Wikipedia

    en.wikipedia.org/wiki/Mode_of_action

    A mechanism of action of a chemical could be "binding to DNA" while its broader mode of action would be "transcriptional regulation". [3] However, there is no clear consensus and the term mode of action is also often used, especially in the study of pesticides, to describe molecular mechanisms such as action on specific nuclear receptors or ...

  4. Monoamine oxidase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor

    Examples of foods and beverages with potentially high levels of tyramine include cheese, Chianti wine, and pickled fish. [25] Excessive concentrations of tyramine in blood plasma can lead to hypertensive crisis by increasing the release of norepinephrine (NE) , which causes blood vessels to constrict by activating alpha-1 adrenergic receptors ...

  5. Minoxidil - Wikipedia

    en.wikipedia.org/wiki/Minoxidil

    The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is an adenosine 5'-triphosphate-sensitive potassium channel opener, [25] causing hyperpolarization of cell membranes.

  6. Monoamine oxidase - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase

    The suggested mechanism for this effect is the decreased ability of those with low MAO-A activity to quickly degrade norepinephrine, the synaptic neurotransmitter involved in sympathetic arousal and rage. This is argued to provide direct support for the idea that genetic susceptibility to disease is not determined at birth, but varies with ...

  7. Mechanism of action of aspirin - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

    The underlying mechanism for the deleterious effect proposes that endothelial cells lining the microvasculature in the body express COX-2, whose selective inhibition results in levels of prostaglandin I2 (PGI2, prostacyclin) down-regulated relative to thromboxane (since COX-1 in platelets is unaffected).

  8. Monoamine neurotransmitter - Wikipedia

    en.wikipedia.org/wiki/Monoamine_neurotransmitter

    Examples are dopamine, norepinephrine and serotonin. All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, and tryptophan by the action of aromatic amino acid decarboxylase enzymes. They are deactivated in the body by the enzymes known as monoamine oxidases which clip off the amine group.

  9. Monoamine oxidase A - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase_A

    MAO-A shares 70% amino acid sequence identity with its homologue MAO-B. [13] Accordingly, both proteins have similar structures. Both MAO-A and MAO-B exhibit an N-terminal domain that binds flavin adenine dinucleotide (FAD), a central domain that binds the amine substrate, and a C-terminal α-helix that is inserted in the outer mitochondrial membrane.