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Here, PIP3 has been implicated in regulating synaptic strengthening and AMPA expression, contributing to long-term potentiation. Moreover, PIP3 suppression disrupts normal AMPA expression on the neuron membrane and instead leads to the accumulation of AMPA on dendritic spines, commonly associated with synaptic depression .
Pip's command-line interface allows the install of Python software packages by issuing a command: pip install some-package-name. Users can also remove the package by issuing a command: pip uninstall some-package-name. pip has a feature to manage full lists of packages and corresponding version numbers, possible through a "requirements" file. [14]
The Python Package Index, abbreviated as PyPI (/ ˌ p aɪ p i ˈ aɪ /) and also known as the Cheese Shop (a reference to the Monty Python's Flying Circus sketch "Cheese Shop"), [2]: 8 [3]: 742 is the official third-party software repository for Python. [4] It is analogous to the CPAN repository for Perl [5]: 36 and to the CRAN repository for R.
The 3D structure of several PH domains has been determined. [11] All known cases have a common structure consisting of two perpendicular anti-parallel beta sheets, followed by a C-terminal amphipathic helix. The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect while providing the ...
Class II and III PI3Ks are differentiated from the Class I by their structure and function. The distinct feature of Class II PI3Ks is the C-terminal C2 domain. This domain lacks critical Asp residues to coordinate binding of Ca 2+, which suggests class II PI3Ks bind lipids in a Ca 2+-independent manner.
Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K/AKT/mTOR pathway. This signal pathway regulates cellular functions such as growth and survival. It ...
On 5 January 1975, the 12-bit field that had been used for dates in the TOPS-10 operating system for DEC PDP-10 computers overflowed, in a bug known as "DATE75". The field value was calculated by taking the number of years since 1964, multiplying by 12, adding the number of months since January, multiplying by 31, and adding the number of days since the start of the month; putting 2 12 − 1 ...
In The Heroes of Olympus, Apollo's Roman descendant Octavian promises the god many things for blessing his prophetic skills, which leads to the Olympians' distraction from the true threat of Gaia, and to the resurgence of Python. As a result, the Delphic Oracle ceases to function, effectively halting demigod quests, and Zeus punishes Apollo.