enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Monoamine oxidase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor

    Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants , especially for treatment-resistant depression and atypical depression . [ 1 ]

  3. Monoamine oxidase - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase

    Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. [ 1 ] [ 2 ] They are found bound to the outer membrane of mitochondria in most cell types of the body.

  4. Monoamine oxidase A - Wikipedia

    en.wikipedia.org/wiki/Monoamine_oxidase_A

    Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. [ 5 ] [ 6 ] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines , such as norepinephrine , serotonin and tyramine .

  5. N,N-Dimethyl-4-methylthioamphetamine - Wikipedia

    en.wikipedia.org/wiki/N,N-Dimethyl-4-methylthio...

    In addition to its MRA activity, 4-MTDMA is a fairly potent monoamine oxidase A (MAO-A) inhibitor, with an IC 50 Tooltip half-maximal inhibitory concentration of 2,100 nM. [4] [5] Potent monoamine oxidase inhibition by amphetamines has been associated with dangerous and sometimes fatal toxicity in humans. [4] [5]

  6. SU-11739 - Wikipedia

    en.wikipedia.org/wiki/SU-11739

    It is a dual or non-selective irreversible monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) inhibitor, with preference for inhibition of MAO-B over MAO-A. [3] [4] It is less selective for MAO-B inhibition than AGN-1135 (racemic rasagiline) or rasagiline. [3]

  7. Brunner syndrome - Wikipedia

    en.wikipedia.org/wiki/Brunner_syndrome

    Brunner syndrome is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and norepinephrine (noradrenaline). In both mice and humans, a mutation was located on the eighth exon of the MAO-A gene, which created a dysfunctional MAO-A gene.

  8. 4-Benzylpiperidine - Wikipedia

    en.wikipedia.org/wiki/4-Benzylpiperidine

    It is most efficacious as a releaser of norepinephrine, with an EC 50 of 109 nM (DA), 41.4 nM (NE), and 5,246 nM . [2] It also functions as a weak monoamine oxidase inhibitor (MAOI) (IC 50 Tooltip half-maximal inhibitory concentration = 130 μM for MAO-A Tooltip monoamine oxidase A and 750 μM for MAO-B Tooltip monoamine oxidase B). [3]

  9. Tranylcypromine - Wikipedia

    en.wikipedia.org/wiki/Tranylcypromine

    Tranylcypromine, sold under the brand name Parnate among others, [1] is a monoamine oxidase inhibitor (MAOI). [4] [7] More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO).