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A third important effect of PTH on the kidneys is stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol). [216] This form of vitamin D is the active hormone which promotes calcium uptake from the intestine via the action of calbindin. [218] Calcitriol also reduces calcium loss to urine. [215]
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4000 IU/d, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, [25] and that there was a single case of toxicity above 10 000 IU after more than seven years of daily intake; this case of toxicity occurred in ...
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
Metamorphic rocks once existed as igneous or sedimentary rocks, but have been subjected to varying degrees of pressure and heat within the Earth's crust. The processes involved will change the composition and fabric of the rock and their original nature is often hard to distinguish. Metamorphic rocks are typically found in areas of mountain ...
Life has made dramatic changes in the environment. Most dramatic was the Great Oxygenation Event, about 2.4 billion years ago, in which photosynthetic organisms flooded the atmosphere with oxygen. Living organisms also catalyze reactions, creating minerals such as aragonite that are not in equilibrium with their surroundings.
Metamorphic rocks are formed by subjecting any rock type—sedimentary rock, igneous rock or another older metamorphic rock—to different temperature and pressure conditions than those in which the original rock was formed. This process is called metamorphism, meaning to "change in form". The result is a profound change in physical properties ...
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