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Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [26] Oral fluconazole is not associated with a significantly increased risk of birth defects overall, although it does increase the odds ratio of tetralogy of Fallot, but the absolute risk is still low. [27] Women using fluconazole during pregnancy have ...
In pregnancy, use on the skin or in the vagina is believed to be safe. [2] There is no evidence of harm when used by mouth during pregnancy but this has been less well studied. [2] When used by mouth, greater care should be taken in those with liver problems. [2] It is in the azole class of medications and works by disrupting the fungal cell ...
Some people are allergic to azole(s). Some azole drugs have adverse side-effects. Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [4] [verification needed] Carbimazole should be used judiciously in pregnancy as it crosses the placenta.
It is unclear if use during pregnancy or breastfeeding is safe. [1] It is in the triazole family of medications. [7] It stops fungal growth by affecting the cell membrane or affecting their metabolism. [7] Itraconazole was patented in 1978 and approved for medical use in the United States in 1992.
Oral ketoconazole has various contraindications, such as concomitant use with certain other drugs due to known drug interactions. [6] Other contraindications of oral ketoconazole include liver disease , adrenal insufficiency , and known hypersensitivity to oral ketoconazole.
A 2023 systematic review looked at 23 records of pregnant animals who were given glucagon-like peptide 1 (GLP-1) agonists — the class of drug Ozempic belongs to — or sodium-glucose co ...
The search for antifungal agents with acceptable toxicity profiles led first to the discovery of ketoconazole, the first azole-based oral treatment of systemic fungal infections, in the early 1980s. Later, triazoles fluconazole and itraconazole , with a broader spectrum of antifungal activity and improved safety profile were developed.
The growing popularity of drugs like Ozempic, Mounjaro and Wegovy, designed to help people with Type 2 diabetes and obesity, has raised new questions about what those drugs could mean for ...