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Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [26] Oral fluconazole is not associated with a significantly increased risk of birth defects overall, although it does increase the odds ratio of tetralogy of Fallot, but the absolute risk is still low. [27] Women using fluconazole during pregnancy have ...
In pregnancy, use on the skin or in the vagina is believed to be safe. [2] There is no evidence of harm when used by mouth during pregnancy but this has been less well studied. [2] When used by mouth, greater care should be taken in those with liver problems. [2] It is in the azole class of medications and works by disrupting the fungal cell ...
It is unclear if use during pregnancy or breastfeeding is safe. [1] It is in the triazole family of medications. [7] It stops fungal growth by affecting the cell membrane or affecting their metabolism. [7] Itraconazole was patented in 1978 and approved for medical use in the United States in 1992.
Ketoconazole is categorized as pregnancy category C in the US. [38] Research in animals has shown it to cause teratogenesis when administered in high doses. [38] A subsequent trial in Europe failed to show a risk to infants of mothers receiving ketoconazole. [39]
Some people are allergic to azole(s). Some azole drugs have adverse side-effects. Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [4] [verification needed] Carbimazole should be used judiciously in pregnancy as it crosses the placenta.
Metformin is just as safe to use during pregnancy to treat type 2 diabetes as insulin, according to new research presented at the Endocrine Society’s ENDO 24 annual meeting this weekend.
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
A 2023 systematic review looked at 23 records of pregnant animals who were given glucagon-like peptide 1 (GLP-1) agonists — the class of drug Ozempic belongs to — or sodium-glucose co ...