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Aspirin is non-selective and irreversibly inhibits both forms [4] (but is weakly more selective for COX-1 [5]). It does so by acetylating the hydroxyl of a serine residue at the 530 amino acid position. [6] Normally COX produces prostaglandins, most of which are pro-inflammatory, and thromboxanes, which promote clotting.
Aspirin helps prevent blood clots from forming, which is the leading cause of heart attack and stroke, but the drug also carries a risk of bleeding. That risk can outweigh aspirin’s benefits in ...
Aspirin can induce swelling of skin tissues in some people. In one study, angioedema appeared one to six hours after ingesting aspirin in some of the people. However, when the aspirin was taken alone, it did not cause angioedema in these people; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared ...
[1] [4] Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. [1] While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. [2] Excess doses can be either on purpose or accidental. [1] Small amounts of oil of wintergreen can be toxic. [2]
Diseases: Coagulation, platelet and blood vessel diseases or deficiencies can increase bruising due to more bleeding. Location: More extensive vascularity causes more bleeding. Areas such as the arms, knees, shins and the facial area are especially common bruise sites. Forces: Greater striking forces cause greater bruising.
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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Bengay and similar products, such as Flexall, Mentholatum, Capzasin and Icy Hot, variously contain menthol, methyl salicylate (oil of wintergreen), and capsaicin as active ingredients and have a potential to cause first-to-third-degree chemical burns. [4] [5] Some people have been hospitalized after receiving such burns. [4]