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A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a sex cord–gonadal stromal tumour of Sertoli cells. They can occur in the testis or ovary. They are very rare and generally peak between the ages of 35 and 50. They are typically well-differentiated and may be misdiagnosed as seminomas as they often appear very similar. [1]
Sertoli–Leydig cell tumour is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group [2] of ovarian and testicular cancers. The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. [ 1 ]
An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body. [ citation needed ]
Androgen-secreting tumors: These are rare tumors that produce androgens and can cause acne in both men and women (though the tumors are more common in women). Deposit Photos Genetics
Androgen-secreting tumors: Tumors in the adrenal glands or in the ovaries leading to increase levels of androgens. [19] Rapid progression and virilization symptoms. [14] Other less common hormonal causes: Acromegaly: Elevated levels of insulin-like growth factor-1. [18] Hyperthyroidism or hypothyroidism: Elevated or decreased levels of thyroid ...
Medical conditions that commonly cause a high-androgen state, such as polycystic ovary syndrome, congenital adrenal hyperplasia, and androgen-secreting tumors, can cause acne in affected individuals. [47] [48] Conversely, people who lack androgenic hormones or are insensitive to the effects of androgens rarely have acne. [47]
Androgen-secreting tumor Though rare, an androgen-secreting tumor (typically found in the adrenal glands or ovaries) may lead to excess hair growth. Other symptoms of this tumor may include a ...
The majority of Leydig cell tumors are found in males, usually at 5–10 years of age or in middle adulthood (30–60 years). Children typically present with precocious puberty. [citation needed] Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization.