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How do drugs like Precose and Glyset work? What kinds of side effects can you expect? When will your doctor prescribe them, and who shouldn't take them?
Alpha-glucosidase inhibitors. Medications. Acarbose; Miglitol (Glyset) Action. Slow the body's ability to breakdown starches and some sugars; Advantages. Don't cause weight gain; Don't cause blood sugar levels to drop too low unless you take them with insulin or a sulfonylurea; Possible side effects. Gas; Stomach pain; Diarrhea
The most common GI side effects were due to the fermentation of unabsorbed carbohydrates and resultant gas production. The severity of GI symptoms may be decreased by dosage reduction and by avoidance of gas-producing foods and sucrose.
When taken alone, these medications do not cause low blood glucose. Common gastrointestinal side effects of these drugs include gas, diarrhea, bloating, and abdominal cramps.
Long-term hyperglycemia can cause several health issues. Insulin resistance is a complex phenomenon. Oral diabetes medications work in different ways to lower blood sugar, including helping your pancreas produce more insulin. Beyond medication, exercise is a key part of naturally reducing insulin resistance.
Reducing the risk of cardiovascular complications — The most common, serious, long-term complication of type 2 diabetes is cardiovascular disease, which can lead to problems like heart attack, stroke, and even death. On average, people with type 2 diabetes have twice the risk of cardiovascular disease as people without diabetes.
OBJECTIVE—To review the effects of monotherapy with α-glucosidase inhibitors (AGIs) for patients with type 2 diabetes, with respect to mortality, morbidity, glycemic control, insulin levels, plasma lipids, body weight, and side effects.
Common alpha glucosidase inhibitors side effects Gastrointestinal (GI) disturbances are the most commonly reported side effects of AGIs. These result from the mechanism of action of the drugs which cause an increase in undigested carbohydrates in the colon leading to excess gas formation.
Alpha-glucosidase inhibitors lower blood glucose by modifying the intestinal absorption of carbohydrates. The glycemic efficacy, adverse effects, and dosing of alpha-glucosidase inhibitors will be discussed here. Other oral hypoglycemic drugs are reviewed separately.
Side effects . Due to the function of alpha-glucosidase inhibitors, gastrointestinal side effects such as: Flatulence (wind) and ; Diarrhoea are common problems for users. However, these effects usually reduce as your body adjusts to the medication.