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Thiazolidinedione. The thiazolidinediones / θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn /, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, [1] are a class of heterocyclic compounds consisting of a five-membered C 3 NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 ...
Thiazolidine is a heterocyclic organic compound with the formula (CH2)3 (NH)S. It is a 5-membered saturated ring with a thioether group and an amine group in the 1 and 3 positions. It is a sulfur analog of oxazolidine. Thiazolidine is a colorless liquid.
Pioglitazone. Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. [3] It may be used with metformin, a sulfonylurea, or insulin. [3][4] Use is recommended together with exercise and diet. [4] It is not recommended in type 1 diabetes. [4] It is taken by mouth.
Pioglitazone is a thiazolidinedione that directly targets insulin resistance, a condition in which the body does not efficiently use the insulin it produces to control blood glucose levels. It is ...
Rosiglitazone. Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with ...
Troglitazone. Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. [1] It was patented in 1983 and approved for medical use in 1997. [2] It was subsequently withdrawn.
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Lobeglitazone. Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
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