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Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body. [10] [9] [7] Because of this, it is considered to be a natural and bioidentical form of testosterone. [17] Testosterone undecanoate was introduced in China for use by injection and in the European Union for use by mouth in the 1970s.
Common side effects of testosterone include acne, swelling, and breast enlargement in men. [9] Serious side effects may include liver toxicity, heart disease, and behavioral changes. [9] Women and children who are exposed may develop masculinization. [9] It is recommended that individuals with prostate cancer should not use the medication. [9]
[85] [62] However, in contrast, the effects of the elevated estrogen levels remain unopposed by bicalutamide, and this is importantly involved in the feminizing side effects (e.g., gynecomastia) of the drug in men. [106] Testosterone levels decline with age in men and younger men have higher testosterone levels on average than older men. [107]
The most infamous flea-to-human transmitted disease is the bubonic plague, which was caused by the bacterium Yersinia pestis. The plague, fevers, tularemia: The diseases fleas can carry and how to ...
[173] [174] In men, a study found that treatment with a relatively low dosage of 20 μg/day ethinylestradiol for 5 weeks increased circulating SHBG levels by 150% and, due to the accompanying decrease free testosterone levels, increased total circulating levels of testosterone by 50% (via reduced negative feedback by androgens on the HPG axis).
The side effects of bicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized. The most common side effects of bicalutamide monotherapy in men include breast tenderness , breast growth , feminization , demasculinization , and hot flashes .
[21] [22] [23] Treatment of men with medical castration and add-back testosterone to restore testosterone levels, with or without the aromatase inhibitor anastrozole, showed that prevention of the conversion of testosterone into estradiol partially prevented restoration of sexual desire and erectile dysfunction by testosterone in men. [32]
Fleas cannot withstand high temperatures, so a turn through the dryer on medium or high kills fleas on clothing. [10] Water and detergent. Fleas can be drowned by immersion for about 24 hours; they may appear to be dead if immersed for shorter times, but can revive after some hours. [11]
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