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The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
In 2009, she published research that showed the mole rat's cells expressed a gene called p16 which prevented tumours from developing. [6] As a result of their "pioneering research on the causes of cancer resistance in naked mole-rats," Gorbunova and Seluanov won the 2009 Cozzarelli Prize. [ 7 ]
In 2018, naked mole-rats were identified as the first mammal to defy the Gompertz–Makeham law of mortality, and achieve negligible senescence. It has been speculated, however, that this may be simply a "time-stretching" effect primarily due to their very slow (and cold-blooded and hypoxic) metabolism. [6] [7] [8]
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The DNA repair transcriptomes of the liver of humans, naked mole-rats and mice were compared. [114] The maximum lifespans of humans, naked mole-rat, and mouse are respectively ~120, 30 and 3 years. The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher ...
However, although these naked mole rats are mammalian, they are highly atypical in terms of aging studies and may not serve as the best model for humans. For example, naked mole rats have a disproportionately high longevity quotient and live in eusocial societies, where breeding is usually designated to a queen. [46]
Groups producing rat gene knockouts and other types of genetically modified rats include the Human and Molecular Genetics Center at MCW. RGD links to information about the rat strains produced in these studies via pages about the PhysGen Knockout project [22] and the MCW Gene Editing Rat Resource Center (GERRC), [23] accessed from RGD page ...
Naked mole rats have high telomerase activity, they live long, and were thought by some to never get cancer; and therefore possibly be an exception to this hypothesis. [34] Naked mole rats do get cancer, however. [35] [36]