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The results were significant: mice treated with the anti-IL-11 drug from 75 weeks of age until their death showed a median lifespan extension of 22.5% in males and 25% in females, living an ...
The results were significant: Researchers found that mice treated with the anti-IL-11 drug showed a median lifespan extension of 22.5% in males and 25% in females, living an average of 155 weeks ...
[8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. [ 1 ] Hence, anti-IL6 agents have been sought.
When used as drugs, the International Nonproprietary Names ... [11] Alzheimer's disease: Afasevikumab [12] mab: human: IL-17A, IL-17F: multiple sclerosis Afelimomab [2]
By the use of recombinant gene technology, the mouse anti-Tac antibodies have been modified, leading to the presentation of two chimeric mouse/human anti-Tac antibodies in the year 1998: basiliximab (Simulect) and daclizumab (Zenapax). These drugs act by binding the IL-2a receptor's α chain, preventing the IL-2 induced clonal expansion of ...
IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. Synonyms are: AGIF; Adipogenesis inhibitory factor; Interleukin-11 precursor. Oprelvekin is produced in Escherichia coli (E. coli) by recombinant DNA technology.
Safety differentiates anti-IL-23p19 treatments from other biologic treatments. There is a theoretical risk of infection and malignancy with the use of any immunosuppressant, including biologics. However, compared with the inhibition of other inflammatory cytokines, IL-23 targeting may only minimally impair the ability to generate a proper ...
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