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A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. [2] Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, [ 2 ] liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients , [ 3 ] such as lipid ...
In lipid polymorphism, if the packing ratio [clarification needed] of lipids is greater or less than one, lipid membranes can form two separate hexagonal phases, or nonlamellar phases, in which long, tubular aggregates form according to the environment in which the lipid is introduced.
The three main structures phospholipids form in solution; the liposome (a closed bilayer), the micelle and the bilayer. [1] The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around all cells.
A unilamellar liposome is a spherical liposome, a vesicle, bounded by a single bilayer of an amphiphilic lipid or a mixture of such lipids, ...
The PTX-embedded cationic liposome interacts with the negatively charged tumor endothelial cells required for tumor angiogenesis, in order to reduce their tumor blood supply. [ 7 ] [ 16 ] Through this mechanism, EndoTAG-1 is able to prevent angiogenesis in the tumor, which in turn inhibits tumor growth. [ 16 ]
Scheme of a liposome formed by phospholipids in an aqueous solution. In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion , uptake (endocytosis), and the transport of materials within the plasma membrane.
First, the involved membranes must aggregate, approaching each other to within several nanometers. Second, the two bilayers must come into very close contact (within a few angstroms). To achieve this close contact, the two surfaces must become at least partially dehydrated, as the bound surface water normally present causes bilayers to strongly ...
Enhanced permeability and retention (EPR) effect and passive targeting. The enhanced permeability and retention (EPR) effect is a controversial concept [1] [2] by which molecules of certain sizes (typically liposomes, nanoparticles, and macromolecular drugs) tend to accumulate in tumor tissue much more than they do in normal tissues.