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The drug is occasionally used on an intermittent basis to prevent seizures in catamenial epilepsy. [10] The sulfur-containing antiseizure and antimigraine drug topiramate is a weak inhibitor of carbonic anhydrase, particularly subtypes II and IV. [11] Whether carbonic anhydrase inhibition contributes to its clinical activity is not known.
Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Dichlorphenamide as a carbonic anhydrase inhibitor is used for the treatment of acute angle closure glaucoma.
Acetazolamide is a carbonic anhydrase inhibitor, hence causing the accumulation of carbonic acid. [12] Carbonic anhydrase is an enzyme found in red blood cells and many other tissues that catalyses the following reaction: [26] H 2 CO 3 ⇌ H 2 O + CO 2. hence lowering blood pH, by means of the following reaction that carbonic acid undergoes: [27]
Topiramate selectively inhibits cytosolic (type II) and membrane-associated (type IV) forms of carbonic anhydrase. Its action on carbonic anhydrase isoenzymes may contribute to the drug's side effects, including its propensity to cause metabolic acidosis and calcium phosphate kidney stones.
Zonisamide and other carbonic anhydrase inhibitors such as topiramate, furosemide, and hydrochlorothiazide have been known to interfere with amobarbital, which has led to inadequate anesthetization during the Wada test. [21] Zonisamide may also interact with other carbonic anhydrase inhibitors to increase the potential for metabolic acidosis. [5]
Pages in category "Carbonic anhydrase inhibitors" The following 42 pages are in this category, out of 42 total. This list may not reflect recent changes. ...
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It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humor. [3] Dorzolamide was approved for medical use in the United States in 1994. [3] It is available as a generic medication. [5] In 2022, it was the 201st most commonly prescribed medication in the United States, with more than 2 million prescriptions. [6] [7]