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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.
The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
1. Ketogenic Diet. Cancer cells rely on glucose for energy to grow. The ketogenic diet is a way to provide an alternative energy source to normal cells in the dog's body while starving the cancer ...
pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril – anticoccidial; praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus; prazosin – sympatholytic used in hypertension and abnormal muscle contractions
The study followed nearly 17 million people, the majority of whom were in the 26-75 age range, and found that after climbing steadily since 2013, rates of obesity in the U.S. fell 0.15% in 2023 ...
The "lion dog" has retained his snuggly ways to this day, according to Dr. O'Callaghan, who says they are "generally friendly and get along well with children, other dogs, and even strangers ...
Various immunosuppressive treatment regimens have been tried, but are not consistently effective. [ 13 ] [ 15 ] Treatment regimens with adrenal steroids and thyroid hormones have been proposed, but as of 2016 no controlled, peer reviewed studies had investigated the effectiveness of such treatments.