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The remaining copy of the tumor suppressor gene can be inactivated by a point mutation or via other mechanisms, resulting in a loss of heterozygosity event, and leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell).
Heterozygosity values of 51 worldwide human populations. [10] Sub-Saharan Africans have the highest values in the world. In population genetics, the concept of heterozygosity is commonly extended to refer to the population as a whole, i.e., the fraction of individuals in a population that are heterozygous for a particular locus. It can also ...
In medical genetics, compound heterozygosity is the condition of having two or more heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state; that is, an organism is a compound heterozygote when it has two recessive alleles for the same gene, but with those two alleles being different from each other (for example, both alleles might be ...
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In population genetics, the Wahlund effect is a reduction of heterozygosity (that is when an organism has two different alleles at a locus) in a population caused by subpopulation structure. Namely, if two or more subpopulations are in a Hardy–Weinberg equilibrium but have different allele frequencies , the overall heterozygosity is reduced ...
Heterozygosity is the fraction of individuals in a population that are heterozygous for a particular locus. Alleles per locus is also used to demonstrate variability. Nucleotide diversity is the extent of nucleotide polymorphisms within a population, and is commonly measured through molecular markers such as micro- and minisatellite sequences ...
Linguistics and languages of Vietnam Nguyễn Văn Lợi (June 9, 1947 – December 20, 2020 [ 1 ] ) was a Vietnamese linguist who served as the deputy director of the Institute of Linguistics (Vietnamese: Viện Ngôn ngữ học ) at the Vietnam Academy of Social Sciences .
Cases of both homozygote and heterozygote advantage have been demonstrated in several organisms, including humans. [8] [9] The first experimental confirmation of heterozygote advantage was with Drosophila melanogaster, a fruit fly that has been a model organism for genetic research.