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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
It is said that "normal concentration in healthy human serum is between 5 and 10 mg/L", but few lines before it is said that people with CRP concentration higher than 3.0 mg/L have a high risk of cardiovascular disease. If you connect these two sentences, you will get that "normal" is something that has "high risk".
C-reactive protein is found in between the beta and gamma zones producing beta/gamma fusion. IgA has the most anodal mobility and typically migrates in the region between the beta and gamma zones also causing a beta/gamma fusion in patients with cirrhosis, respiratory infection, skin disease, or rheumatoid arthritis (increased IgA).
Normal values of ESR have been quoted as 1 [24] to 2 [25] mm/h at birth, rising to 4 mm/h 8 days after delivery, [25] and then to 17 mm/h by day 14. [24] Typical normal ranges quoted are: [6] Newborn: 0 to 2 mm/h; Neonatal to puberty: 3 to 13 mm/h, but other laboratories place an upper limit of 20. [26]
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In contrast, C-reactive protein (with a half-life of 6–8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. For example, in active systemic lupus erythematosus, one may find a raised ESR but normal C-reactive protein. [citation needed] They may also indicate liver failure. [11]
The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.