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Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation. [1]
Melanin-concentrating hormone receptor 1, also known as MCH 1, is one of the melanin-concentrating hormone receptors found in all mammals. [5]The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone.
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology. MCH-R1 is expressed in all mammals. MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.
Melanin-concentrating hormone receptor 2 (MCH 2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene. [3] [4] [5]MCH 2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats.
SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH 1.In initial animal studies it had promising anxiolytic, antidepressant and anorectic effects, [1] [2] but subsequent trial results were disappointing, [3] and the main significance of SNAP-7941 is as the lead compound from which more potent and ...
The zona incerta together with the hypothalamus is one of the two areas of the brain that produces the neuropeptide melanin concentrating hormone. [11] Dopaminergic ones are also more prevalent. [9] There are in addition populations of cells producing somatostatin, angiotensin II and melanocyte stimulating hormone. [9]
Melanin-concentrating hormone, which official gene name is PMCH This page was last edited on 30 March 2022, at 15:46 (UTC). Text is available under the Creative ...
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH).