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Atrial septal defect (ASD) is a congenital heart defect in which blood flows between the atria (upper chambers) of the heart. Some flow is a normal condition both pre-birth and immediately post-birth via the foramen ovale ; however, when this does not naturally close after birth it is referred to as a patent (open) foramen ovale (PFO).
The ostium primum atrial septal defect is a defect in the atrial septum at the level of the tricuspid and mitral valves. This is sometimes known as an endocardial cushion defect because it often involves the endocardial cushion, which is the portion of the heart where the atrial septum meets the ventricular septum and the mitral valve meets the tricuspid valve.
Foramen secundum atrial septal defects are the most common atrial septal defects. This defect can arise as a result of defects of the septum primum and the septum secundum. For the septum primum, the problem can arise as a result of excess resorption of the septum during the process of apoptosis in order to form the foramen secundum.
An atrial septal defect is a congenital heart defect where the septum between the right and left atrium doesn’t close up all the way and remains open after birth. This causes oxygenated blood to go into pulmonary circulation. One complication from this condition is a paradoxical embolus which crosses from the right to the left side via the ASD.
The gap below it is known as the ostium primum (from Latin 'first opening'), and becomes increasingly small. The septum primum eventually fuses with the endocardial cushion, closing the ostium primum off completely. Meanwhile, perforations appear in the superior part of the septum primum, forming the ostium secundum (from Latin 'second opening').
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The septum primum, a septum which grows down to separate the primitive atrium into the left atrium and right atrium, grows in size over the course of heart development. The primary interatrial foramen is the gap between the septum primum and the septum intermedium , which gets progressively smaller until it closes.
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