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Medulloblastoma is the second-most frequent brain tumor in children after pilocytic astrocytoma [37] and the most common malignant brain tumor in children, comprising 14.5% of newly diagnosed brain tumors. [38] In adults, medulloblastoma is rare, comprising fewer than 2% of CNS malignancies. [39]
The most common brain tumor types in children (0–14) are: pilocytic astrocytoma, malignant glioma, medulloblastoma, neuronal and mixed neuronal-glial tumors, and ependymoma. [106] In children under 2, about 70% of brain tumors are medulloblastomas, ependymomas, and low-grade gliomas.
Classification of brainstem gliomas by MRI appearance. Histopathology of a brainstem glioma. A brainstem glioma is a cancerous glioma tumor in the brainstem.Around 75% are diagnosed in children and young adults under the age of twenty, but have been known to affect older adults as well. [1]
For children experiencing seizures, an EEG might be part of the diagnostic process (the goal being to record the brain's electrical activity in order to identify and localize seizure activity). Finally, a biopsy of the tumor, taken through a needle during a simple surgical procedure, helps to confirm the diagnosis.
Removal of tumor tissues helps decrease the pressure of the tumor on nearby parts of the brain. [17] The main goal of surgery is to remove as much as possible of the tumor mass while preserving normal brain function, and to relieve the symptoms caused by the tumor such as headache, nausea and vomiting. [18]
Pilocytic astrocytoma (and its variant pilomyxoid astrocytoma) is a brain tumor that occurs most commonly in children and young adults (in the first 20 years of life). They usually arise in the cerebellum, near the brainstem, in the hypothalamic region, or the optic chiasm, but they may occur in any area where astrocytes are present, including the cerebral hemispheres and the spinal cord.
Less than 50% of children survive more than 5 years, [1] while the majority of adults live to 7 years. [2] The reason the prognosis for such tumor is worst in children is due to the higher probability of the tumor spreading to the rest of the nervous system through the cerebrospinal fluid and growing again. [2]
Brain tumors are the most common type of solid tumors to affect the pediatric population. [ 3 ] In particular, medulloblastoma is the most common of them, and constitutes about 20% of all the malignant pediatric brain tumors, classified as a primitive neuroectodermal tumor (PNET) of the cerebellum.
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