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Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; [1] EC 2.3.2.2) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate).
21818 Ensembl ENSG00000125780 ENSMUSG00000027401 UniProt Q08188 Q08189 RefSeq (mRNA) NM_003245 NM_009374 RefSeq (protein) NP_003236 NP_033400 Location (UCSC) Chr 20: 2.3 – 2.34 Mb Chr 2: 129.85 – 129.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse For the Tetris game, see Tetris: The Grand Master. Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is ...
Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion.
In prokaryotes, it has been found that transport does not require Cl −. In mammals, the Cl − ion is required to offset the positive charge of the Na + in order to maintain the proper membrane potential. [10] Occluded-out. Once fully loaded, this conformation prevents the release of ions/substrate into the cytoplasm or the extracellular ...
TG2 is a multifunctional enzyme that belongs to transglutaminases which catalyze the crosslinking of proteins by epsilon-(gamma-glutamyl)lysine isopeptide bonds. [15] Similarly to other transglutaminases, tTG consists of a GTP/ GDP binding site, a catalytic domain , two beta barrel and a beta-sandwich . [ 16 ]
GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).
Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene. [5] [6] [7] [8]Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4).
331046 Ensembl ENSG00000163810 ENSG00000281886 ENSMUSG00000025787 UniProt P49221 Q8BZH1 RefSeq (mRNA) NM_003241 NM_177911 RefSeq (protein) NP_003232 NP_808579 Location (UCSC) Chr 3: 44.87 – 44.91 Mb Chr 9: 122.86 – 122.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene. References ...