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The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3). [ 1 ] [ 2 ] [ 3 ] The method involves the reaction of an α- amino - ketone (1) and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2) .
The Knorr pyrrole synthesis involves the reaction of an α-amino ketone or an α-amino-β-ketoester with an activated methylene compound. [15] [16] [17] The method involves the reaction of an α-amino ketone (1) and a compound containing a methylene group α to (bonded to the next carbon to) a carbonyl group (2). [18] The Knorr pyrrole synthesis
The Hantzsch Pyrrole Synthesis, named for Arthur Rudolf Hantzsch, is the chemical reaction of β-ketoesters (1) with ammonia (or primary amines) and α-haloketones (2) to give substituted pyrroles (3).
2-mesityl-3-methylpyrrole was synthesized in 2004 via the Trofimov reaction. The reaction of the ketoxime with acetylene yielded a mixture of products with the primary one being the N-H pyrrole. Small amounts of the N-vinyl product were also observed as well as O-vinylketoxime. The N-vinyl product was then used in the synthesis of a new BODIPY. [5]
In organic chemistry, the Paal–Knorr synthesis is a reaction used to synthesize substituted furans, pyrroles, or thiophenes from 1,4-diketones.It is a synthetically valuable method for obtaining substituted furans and pyrroles, which are common structural components of many natural products.
He performed the porphin synthesis at a temperature of 90-95 °C and high pressure in sealed pyrex glass tubes, by reacting pyrrole, 2 % formaldehyde and pyridine in methanol for 30 hours. [7] A simplified version of Rothemund porphyrin synthesis was described by Alan D. Adler and Frederick R. Longo in 1966.
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The Barton–Zard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanide under basic conditions. [1] It is named after Derek Barton and Samir Zard who first reported it in 1985.