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Ulixacaltamide is an investigational new drug developed by Praxis Precision Medicines, designed to treat essential tremor, [1] a common neurological disorder characterized by involuntary rhythmic shaking.
Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures [7] and essential tremors. [8] It is taken by mouth. [7] Its common side effects include sleepiness, poor coordination, nausea, and loss of appetite. [7] Severe side effects may include suicide and ...
Essential tremor (ET), also called benign tremor, familial tremor, and idiopathic tremor, is a medical condition characterized by involuntary rhythmic contractions and relaxations (oscillations or twitching movements) of certain muscle groups in one or more body parts of unknown cause. [6]
The drug, called suvecaltamide, was being tested in adults with essential tremor, a condition that affects the nervous system and causes involuntary and rhythmic shaking, affecting about 10 ...
Hence, the drug is theorized to have improved tolerability. [4] [5] [6] PRAX-114 shows antidepressant-like, anxiolytic-like, and, at higher doses, sedative effects in animals. [4] [5] [6] As of March 2023, PRAX-114 is in phase 2/3 clinical trials for major depressive disorder and phase 2 clinical trials for essential tremor.
Tremors that are worse at rest include Parkinsonian syndromes and essential tremor if severe. This includes drug-induced tremors from blockers of dopamine receptors such as haloperidol and other antipsychotic drugs. During contraction (e.g. a tight fist while the arm is resting and supported) Contraction tremors
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