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2. Mechanism of action of aspirin - Wikipedia

   en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

   Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]

3. Aspirin - Wikipedia

   en.wikipedia.org/wiki/Aspirin

   By 1899, Bayer had dubbed this drug Aspirin and was selling it globally. [16]: 27 The word Aspirin was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries. Aspirin's popularity grew over the first half of the 20th century leading to fierce competition with ...

4. Enteric coating - Wikipedia

   en.wikipedia.org/wiki/Enteric_coating

   An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]

5. Daily low-dose aspirin has its benefits — and risks. Here's ...

   www.aol.com/lifestyle/aspirin-every-day-why-not...

   Aspirin helps prevent blood clots from forming, which is the leading cause of heart attack and stroke, but the drug also carries a risk of bleeding. That risk can outweigh aspirin’s benefits in ...

6. Route of administration - Wikipedia

   en.wikipedia.org/wiki/Route_of_administration

   Enteric coated tablets are designed to dissolve in the intestine, not the stomach, because the drug present in the tablet causes irritation in the stomach. Administering medication rectally The rectal route is an effective route of administration for many medications, especially those used at the end of life .

7. Tablet (pharmacy) - Wikipedia

   en.wikipedia.org/wiki/Tablet_(pharmacy)

   Enteric coatings are also used for medicines that can be negatively affected by taking a long time to reach the small intestine, where they are absorbed. Coatings are often chosen to control the rate of dissolution of the drug in the gastrointestinal tract. Some drugs are absorbed better in certain parts of the digestive system.

8. Absorption (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Absorption_(pharmacology)

   In the stomach, drugs that are weak acids (such as aspirin) will be present mainly in their non-ionic form, and weak bases will be in their ionic form. Since non-ionic species diffuse more readily through cell membranes , weak acids will have a higher absorption in the highly acidic stomach .

9. Compound analgesic - Wikipedia

   en.wikipedia.org/wiki/Compound_analgesic

   Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets. One example is APC (aspirin, phenacetin, and caffeine) compound tablets common from the 1940s to 1983; because of harmful side effects of phenacetin, Anacin in the U.S. was reformulated to eliminate it; while Vincent's APC is ...