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4-Aminophenol is a building block used in organic chemistry. Prominently, it is the final intermediate in the industrial synthesis of paracetamol. Treating 4-aminophenol with acetic anhydride gives paracetamol: [8] [9] [10] It is a precursor to amodiaquine, mesalazine, AM404, parapropamol, B-86810 & B-87836 (c.f. WO 2001042204 ).
4-Aminophenol may be obtained by the amide hydrolysis of paracetamol. This reaction is also used to determine paracetamol in urine samples: After hydrolysis with hydrochloric acid, 4-aminophenol reacts in ammonia solution with a phenol derivate, e.g. salicylic acid, to form an indophenol dye under oxidization by air. [139]
AM404, also known as N-arachidonoylphenolamine, [1] [2] is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action [3] and anticonvulsant effects. [4] Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 is one of the AM cannabinoids discovered by Alexandros ...
The three aminophenol isomers: Left: 2-Aminophenol (o-aminophenol) Center: 3-Aminophenol (m-aminophenol) Right: 4-Aminophenol (p-aminophenol) Aminophenol may refer to any of three isomeric chemical compounds: 2-Aminophenol; 3-Aminophenol; 4-Aminophenol; They are simultaneously an aniline and a phenol
In adults, a dose of 6 grams a day over the preceding 48 hours could potentially lead to toxicity, [20] while in children acute doses above 200 mg/kg could potentially cause toxicity. [24] Acute paracetamol overdose in children rarely causes illness or death, and it is very uncommon for children to have levels that require treatment, with ...
Alkylphenols are xenoestrogens. [3] Long chain Alkylphenols have the most potent estrogenic activity. [3] The European Union has implemented sales and use restrictions on certain applications in which nonylphenols are used because of their alleged "toxicity, persistence, and the liability to bioaccumulate" but the United States EPA has taken a slower approach to make sure that action is based ...
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4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. [2] Specifically it is used to treat active drug resistant tuberculosis together with other antituberculosis medications . [ 3 ]