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Side effects in humans may include poor coordination, abdominal pain, vomiting, headache, and allergic reactions. [4] While it may be used during pregnancy, it is not recommended for use during breastfeeding. [4] Praziquantel is in the anthelmintic class of medications. [3] It works partly by affecting the function of the worm's sucker. [3]
Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to Schistosoma mansoni. [1] Praziquantel, however, is often the preferred treatment. [2] It is given by mouth and used as a single dose. [2] Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine. [1]
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel. [1]
Sm-p80-based vaccine formulation(s) have four effects: Reduction in adult worm numbers; Reduction in egg production (complete elimination of egg induced pathology both in baboons and mice); Protection against acute schistosomiasis; Therapeutic effect on adult worms. This vaccine is now ready for human clinical trials. [5] [6] [7] Another target ...
A schistosomicide is a drug used to combat schistosomiasis. [1] ... Schistosomiasis vaccine; ... "Current chemotherapy arsenal for schistosomiasis mansoni ...
Schistosomiasis is treatable by taking by mouth a single dose of the drug praziquantel annually. [66] Praziquantel only eliminates the adult schistosomes, but it is not effective in killing the eggs and immature worms. [19] Live eggs can be excreted by the infected individuals for weeks after treatment with praziquantel. [19]
Deworming programmes for children usually administer an anthelmintic drug such as albendazole or mebendazole (or praziquantel in a weight based or height based dose for schistosomiasis). The treatment is given as a single dose in a pill formulation.
Praziquantel is the drug of choice for schistosomiasis, taeniasis, and most types of food-borne trematodiases. Oxamniquine is also widely used in mass deworming programmes. Pyrantel is commonly used for veterinary nematodiasis. [45] [46] Artemisinins and derivatives are proving to be candidates as drugs of choice for trematodiasis. [47]
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