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Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes , MODY is a form of the conditions known as monogenic diabetes.
MODY 3 or HNF1A-MODY is a form of maturity-onset diabetes of the young.It is caused by mutations of the HNF1-alpha gene, a homeobox gene on human chromosome 12.This is the most common type of MODY in populations with European ancestry, [1] accounting for about 70% of all cases in Europe.
This type of neonatal diabetes is caused by activating mutations of the KCNJ11 gene, which codes for the Kir6.2 subunit of the beta cell K ATP channel. [1] [2] This disease is considered to be a type of maturity onset diabetes of the young (MODY).
The onset of NDM can be caused by abnormal pancreatic development, beta cell dysfunction or accelerated beta cell dysfunction. [3] Along with maturity-onset diabetes of the young (MODY), NDM is a form of monogenic diabetes. Individuals with monogenic diabetes can pass it on to their children or future generations.
MODY 6 or NEUROD1-MODY is a form of maturity onset diabetes of the young. MODY 6 arises from mutations of the gene for the transcription factor referred to as neurogenic differentiation 1. The gene is on chromosome 2 in a region of the p arm known as IDDM7 because it includes genes affecting susceptibility to diabetes mellitus type 1 (NeuroD1). [1]
These include maturity onset diabetes of the young (MODY), Donohue syndrome, and Rabson–Mendenhall syndrome, among others. [1] Maturity onset diabetes of the young constitute 1–5% of all cases of diabetes in young people. [3]
While certain kinds of diabetes, like type 1 diabetes, can come on quickly, the most common type—type 2 diabetes—can be a slower process. People with excess weight and a sedentary lifestyle ...
MODY 2 or GCK-MODY is a form of maturity-onset diabetes of the young. [1] It is due to any of several mutations in the GCK gene on human chromosome 7 for glucokinase. [2] Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion as the glucose exceeds about 90 mg/dl (5 mM).