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This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 77 ] [ 79 ] [ 80 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 77 ]
More serious side effects may include suicidal thoughts in people up to the age of 24 years. [9] It is unclear if use during pregnancy or breastfeeding is safe. [ 10 ] Escitalopram is the ( S )- enantiomer of citalopram (which exists as a racemate ), hence the name es -citalopram.
Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old, and an increased risk of bleeding. [2] Antidepressant discontinuation syndrome is less likely to occur with fluoxetine than with other antidepressants, but it still happens in many cases.
Side effects. SSRIs are generally less likely to cause side effects than older antidepressants, but adverse effects still happen for some people. Common SSRI side effects include nausea, agitation ...
In clinical trials, the pills eased depression without the sexual side effects that can push some people to quit SSRIs. And there were no adverse effects on weight, blood pressure, heart rate, or ...
Some prescription antidepressants, such as bupropion (Wellbutrin), are less likely to cause intimate side effects than others in the SSRI class of medications. Taking a temporary “drug holiday.”
Like other SSRIs, sertraline is associated with sexual side effects, including sexual arousal disorder, erectile dysfunction and difficulty achieving orgasm. While nefazodone and bupropion do not have negative effects on sexual functioning, 67% of men on sertraline experienced ejaculation difficulties versus 18% before the treatment. [92]
Medifoxamine (Cledial, Gerdaxyl) is an antidepressant that appears to act as an SDRI as well as a 5-HT 2 receptor antagonist. [3] Sibutramine (Reductil, Meridia, Siredia, Sibutrex) is a withdrawn anorectic that itself as a molecule in vitro is an SNDRI but preferentially an SDRI, with 18.3- and 5.8-fold preference for inhibiting the reuptake of serotonin and dopamine over norepinephrine ...
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