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Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [150] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 μg of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 μg. The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent ...
Cobalt is essential to the metabolism of all animals. It is a key constituent of cobalamin, also known as vitamin B 12, the primary biological reservoir of cobalt as an ultratrace element. [1] [2] Bacteria in the stomachs of ruminant animals convert cobalt salts into vitamin B 12, a compound which can only be produced by bacteria or archaea.
How vitamin B12 deficiency is detected. If a doctor suspects a vitamin B12 deficiency, they will usually order blood work to check a patient’s levels, Kaiser says. But having lower vitamin B12 ...
Vitamin deficiency is the condition of a long-term lack of a vitamin.When caused by not enough vitamin intake it is classified as a primary deficiency, whereas when due to an underlying disorder such as malabsorption it is called a secondary deficiency.
selenium deficiency / selenosis: Cobalt: none NE; NE: Cobalt is available for use by animals only after having been processed into complex molecules (e.g., vitamin B 12) by bacteria. Humans contain only milligrams of cobalt in these cofactors. A deficiency of cobalt leads to pernicious anemia.
Cobalt is essential to the metabolism of all animals. It is a key constituent of cobalamin, also known as vitamin B 12, the primary biological reservoir of cobalt as an ultratrace element. [187] [188] Bacteria in the stomachs of ruminant animals convert cobalt salts into vitamin B 12, a compound which can only be produced by bacteria or archaea.
Methylcobalamin is equivalent physiologically to vitamin B 12, [3] and can be used to prevent or treat pathology arising from a lack of vitamin B 12 intake (vitamin B 12 deficiency). Methylcobalamin is also used in the treatment of peripheral neuropathy , diabetic neuropathy , and as a preliminary treatment for amyotrophic lateral sclerosis .